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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRS2
All Species:
6.06
Human Site:
S643
Identified Species:
12.12
UniProt:
Q9Y4H2
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y4H2
NP_003740.2
1338
137334
S643
E
I
G
S
H
R
S
S
S
S
N
L
G
A
D
Chimpanzee
Pan troglodytes
XP_529580
1133
115941
S483
G
S
H
R
S
S
S
S
N
L
G
A
D
D
G
Rhesus Macaque
Macaca mulatta
XP_001109882
1252
133053
R600
E
R
R
G
G
H
H
R
P
D
S
S
T
L
H
Dog
Lupus familis
XP_542667
1132
119070
Y482
S
S
A
S
L
D
E
Y
T
L
M
R
A
T
F
Cat
Felis silvestris
Mouse
Mus musculus
P81122
1321
136508
S639
E
I
G
S
H
K
S
S
S
S
N
L
G
A
D
Rat
Rattus norvegicus
P35570
1235
131160
M585
Y
P
E
E
G
L
E
M
H
H
L
E
R
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505439
368
40215
Chicken
Gallus gallus
XP_425588
735
76788
G85
P
P
V
R
D
S
G
G
G
T
D
L
Y
G
Y
Frog
Xenopus laevis
P84770
1088
119088
F438
P
C
D
F
R
S
S
F
R
S
V
T
P
D
S
Zebra Danio
Brachydanio rerio
XP_700746
1062
115299
G412
S
G
S
P
S
D
A
G
F
I
S
C
D
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9XTN2
968
107813
G318
S
S
N
Q
T
Y
F
G
S
N
H
G
L
R
S
Honey Bee
Apis mellifera
XP_391985
1190
129451
P540
H
S
H
H
K
Y
S
P
N
F
K
S
H
S
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.5
36.8
75.6
N.A.
85.1
36
N.A.
20.3
35.2
38.1
49.4
N.A.
21
21
N.A.
N.A.
Protein Similarity:
100
83.3
48.8
77.5
N.A.
88
48.1
N.A.
23.1
42.5
49.7
59.3
N.A.
35.9
35.7
N.A.
N.A.
P-Site Identity:
100
13.3
6.6
6.6
N.A.
93.3
0
N.A.
0
6.6
13.3
0
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
20
13.3
13.3
N.A.
100
0
N.A.
0
20
13.3
13.3
N.A.
20
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
9
0
0
0
0
9
9
17
0
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
9
% C
% Asp:
0
0
9
0
9
17
0
0
0
9
9
0
17
17
17
% D
% Glu:
25
0
9
9
0
0
17
0
0
0
0
9
0
9
0
% E
% Phe:
0
0
0
9
0
0
9
9
9
9
0
0
0
0
9
% F
% Gly:
9
9
17
9
17
0
9
25
9
0
9
9
17
9
17
% G
% His:
9
0
17
9
17
9
9
0
9
9
9
0
9
0
9
% H
% Ile:
0
17
0
0
0
0
0
0
0
9
0
0
0
0
0
% I
% Lys:
0
0
0
0
9
9
0
0
0
0
9
0
0
0
0
% K
% Leu:
0
0
0
0
9
9
0
0
0
17
9
25
9
9
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
17
9
17
0
0
0
0
% N
% Pro:
17
17
0
9
0
0
0
9
9
0
0
0
9
0
9
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
9
17
9
9
0
9
9
0
0
9
9
17
0
% R
% Ser:
25
34
9
25
17
25
42
25
25
25
17
17
0
9
17
% S
% Thr:
0
0
0
0
9
0
0
0
9
9
0
9
9
9
0
% T
% Val:
0
0
9
0
0
0
0
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
17
0
9
0
0
0
0
9
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _